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Translesion synthesis during interstrand crosslink repair. Interstrand crosslinks can be induced by cisplatin, mitomycin C, psoralen and abasic sites. Cisplatin and mitomycin C are repaired by the Fanconi anemia pathway (A), whereas psoralen and abasic site induced ICL are repaired through NEIL3-dependent pathway (B andC). Figure adapted from (23).
