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Structure of the miR-21-targeted peptide-oligonucleotide conjugate, miR-21-miRNase. (A) Sequence of oligonucleotide part of miRNase and schematic representation of a general complex of miR-21 and miRNase. (B) Chemical structure of miRNase. The peptide acetyl-[(LeuArg)2Gly]2 was covalently attached via its C-terminus to the aminohexyl linker located at the 5′-terminal phosphate of the antisense oligonucleotide.
