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. 2019 Aug 7;10:1745. doi: 10.3389/fimmu.2019.01745

Figure 1.

Figure 1

Schematic representation of the structure and function of NLRP1, NLRP3, NLRC4/IPAF, AIM2, and Pyrin Inflammasomes. Shown are the minimal NLRP1, NLRP3, NLRC4/IPAF, AIM2, and pyrin inflammasomes, their corresponding stimulation signals, described resulting downstream effects and associated disorders. Formation of the inflammasome initiates autocatalytic activation of caspase-1, resulting in cleavage of the pro-enzyme into the active p20 and p10 subunits. The active enzyme is assembled in the form of heterodimers and cause release of mature IL-1β/IL-18 and gasdermin D cleavage.