Figure 1.

Performance Comparison of DPR versus PrediXcan

Plots of average imputation R² (A) and TWAS power (B) in test samples by DPR and PrediXcan, with various proportions of true causal SNPs p_causal = (0.001, 0.01, 0.1, 0.2) and true expression heritability ${\text{h}}_{\text{e}}^2=\left(0.05,0.1,0.2,0.5\right)$. TWAS power was evaluated with paired expression and phenotype heritability $\left({\text{h}}_{\text{e}}^2,{\text{h}}_{\text{p}}^2\right)=\left(\left(0.05,0.8\right),\left(0.1,0.5\right),\left(0.2,0.25\right),\left(0.5,0.1\right)\right)$.