Table 1.
Induction of EAE or EAN and antimyelin antibodies by myelin antigens.
| Antigens | EAE/EAN | Antibodies | |||
|---|---|---|---|---|---|
| Demyelinating | Myelination Inhibiting | ||||
| CNS | PNS | CNS | PNS | ||
| CNS Antigens | |||||
| Whole CNS | + | + | - | + | - |
| MBP | + | - | - | - | ND |
| GC | - | + | + | + | + |
| M2 | ND | + | ND | ND | ND |
| MAG | - | - | - | - | ND |
| PLP | + | - | - | - | ND |
| GM1 | ± a | - | - | - | - |
| CMIP | ± b | + | - | + | ND |
| MOG | + | + | ND | ND | ND |
| PNS Antigens | |||||
| Whole PNS | + | ± | + | + | + |
| P2 protein | ± | - | - | - | - |
ND: not determined; EAE: experimental allergic encephalomyelitis; EAN: experimental allergic neuritis; CNS: central nervous system; PNS: peripheral nervous system; MBP: myelin basic protein; GC: galactocerebroside; MAG: myelin-associated glycoprotein; PLP: proteolipid protein; CMIP: chloroform-methanol insoluble protein; MOG: myelin oligodendrocyte glycoprotein. a Several reports of induction of an experimental demyelinating disease in rabbits. b No clinical EAE but occasional inflammatory infiltrates histologically.