Table 1.

List of mutations in the hinge and constant heavy chain domain 2 (C_H2) regions of different silent immunoglobulin (IgG) designs.

	IgG1 AA	IgG1σ	IgG1 FES	IgG2σ	IgG4 PAA	IgG4σ1	IgG4σ2
Core hinge					S228P	S228P	S228P
Lower hinge	L234A	L234A	L234F	V234A	F234A	F234A	F234A
	L235A	L235A	L235E		L235A	L235A	L235A
							∆G236
		G237A		G237A		G237A	G237A
		P238S		P238S		P238S	P238S
CH2 domain of Fc		H268A		H268A
				V309L
		A330S		A330S
		P331S	P331S	P331S

Δ Indicates deletion of residue. European Union (EU) numbering is used for the amino acid substitutions.