Table 6.
Dynamic light scattering data after low pH treatment.
| Ab1 | Avg Rh | Avg %Pd | Avg %Mass | Avg Rh | Avg %Pd | Avg %Mass |
|---|---|---|---|---|---|---|
| Release Material | Low pH Material | |||||
| IgG1 | 5.4 ± 0.1 | 10.3 ± 2.1 | 100.0 ± 0.0 | 5.1 ± 0.2 | 12.2 ± 1.7 | 100.0 ± 0.0 |
| IgG1σ | 5.4 ± 0.0 | 9.6 ± 0.3 | 100.0 ± 0.0 | 5.0 ± 0.2 | 13.2 ± 0.8 | 100.0 ± 0.0 |
| IgG1 AA | 5.8 ± 0.3 | 16.7 ± 10.1 | 100.0 ± 0.1 | 5.5 ± 0.2 | 12.2 ± 7.1 | 100.0 ± 0.0 |
| IgG1 FES | 5.5 ± 0.0 | 7.7 ± 1.6 | 100 ± 0.0 | 5.2 ± 0.1 | 11.9 ± 1.3 | 99.7 ± 0.6 |
| IgG2 | 5.8 ± 0.1 | 18.2 ± 5.2 | 99.6 ± 0.1 | 5.0 ± 0.1 | 13.2 ± 0.6 | 100.0 ± 0.0 |
| IgG2σ | 5.4 ± 0.0 | 13.0 ± 3.6 | 100.0 ± 0.0 | 5.1 ± 0.2 | 12.5 ± 1.5 | 99.6 ± 0.8 |
| IgG4—PAA | 5.3 ± 0.1 | 9.9 ± 0.6 | 100.0 ± 0.0 | 5.3 ± 0.0 | 10.4 ± 0.8 | 100.0 ± 0.0 |
| IgG4σ1 | 5.4 ± 0.1 | 9.3 ± 0.5 | 100.0 ± 0.0 | 6.4 ± 0.2 | 15.5 ± 1.6 | 100.0 ± 0.0 |
| IgG4σ2 | 5.4 ± 0.0 | 8.9 ± 0.4 | 100.0 ± 0.0 | 6.6 ± 0.1 | 14.8 ± 1.3 | 100.0 ± 0.0 |
Samples were tested at 1 mg/mL in triplicate and shown as mean ± standard deviation (STD). Avg—average; Percent polydispersity (% Pd); hydrodynamic radius (Rh).