Figure 1.

Distribution of Risk Allele Frequency and Estimated Odds Ratio for 48 Autosomal Variants Previously Identified in Vitiligo GWAS123

Each dot represents the most-associated variant for a vitiligo susceptibility locus, and each locus is labeled with a gene in close proximity to the most-associated variant in the locus. Dot and label colors represent the likely functional category of the locus, designated by manual review of each locus: orange = apoptosis, green = immune regulation, blue = functional component of the melanocyte, and pink = unknown function. ^∗ denotes an HLA-DQB1 locus specifically associated in early-onset vitiligo cases;¹² the effect size used for the HLA-DQB1 variant here was derived from all vitiligo cases, regardless of the age of onset.