Table 1.
Risk of Vitiligo Associated with High CONFIRMED and FAMILY Risk Scores
| High-Risk Score Groupa | Reference Group |
CONFIRMED Risk Score |
FAMILY Risk Scorec |
|||
|---|---|---|---|---|---|---|
| Minimum Risk Scoreb | GWAS123 OR (95% CI) | Replication OR (95% CI) | Minimum Risk Scoreb | GWAS123 OR (95% CI) | ||
| Top 20% of distribution | Remaining 80% | 0.84 | 5.32 (4.90–5.77) | 4.87 (4.21–5.64) | 0.84 | 3.20 (2.95–3.47) |
| Top 10% of distribution | Remaining 90% | 1.29 | 6.21 (5.70–6.76) | 5.26 (4.42–6.29) | 1.30 | 3.50 (3.19–8.84) |
| Top 5% of distribution | Remaining 95% | 1.66 | 7.33 (6.64–8.08) | 6.20 (4.96–7.79) | 1.69 | 3.83 (3.42–4.29) |
| Top 1% of distribution | Remaining 99% | 2.35 | 11.10 (9.41–13.10) | 8.79 (5.85–13.78) | 2.39 | 4.51 (3.63–5.59) |
Abbreviations are OR - odds ratio and CI = confidence interval.
a
Risk score distribution defined by GWAS123 controls.
b
Minimum normalized risk score to be assigned to the high-risk group; the normalized score represents the standard deviations above the mean in GWAS123 controls.
c
FAMILY risk score cannot be calculated in the replication study because replication samples were not genotyped at all of the variants included in the FAMILY risk score.