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. Author manuscript; available in PMC: 2019 Aug 19.
Published in final edited form as: Brain Behav Immun. 2018 Feb 1;69:532–539. doi: 10.1016/j.bbi.2018.01.012

Figure 3. Minocycline inhibited nucleus accumbens shell microglial activation in response to ethanol.

Figure 3.

A) TBI significantly increased the percent of Iba1-positive microglia in the nucleus accumbens shell that co-express CD68 following a single IP injection of ethanol. Treatment with minocycline significantly reduced the percent of co-localized Iba1/CD68-positive microglia. B) Representative images of microglia in the ipsilateral nucleus accumbens shell following ethanol injection. Iba1 staining is shown in red, CD68 staining is shown in green. Scale bar = 20 µm. C) The percent of Iba1-positive microglia that co-express CD68 in the nucleus accumbens shell, core, and ventral tegmental area are represented as percent (± one standard error).