Figure 3.

Graphical Representation of Possible Mechanisms by which EBV miRNAs Contribute to the Progression of EBV-Associated Malignancies

EBV miRNAs can govern multiple cellular and signaling machineries. EBV miRNAs function in regulation of cell proliferation and apoptosis, silencing of tumor suppressors, promotion of the EMT program, invasion and metastasis, as well as subversion of host immune surveillance. Therefore, EBV miRNAs play an important role in the etiology of EBV-associated malignancies.