Table 1.

Patient characteristics of included patient cohorts of non‐G‐CIMP GBMs

Variables	Training set		Validation set
	Rennes cohort	TCGA	GSE60274
Sample size	77	102	59
Clinical factors
Age
Median	60	63	52
Range	36‐75	23‐85	26‐70
Pre‐operative KPSa
Median	80	80	NA
Range	40‐100	40‐100	NA
Gender
Male/Female	55/22	58/44	45/14
Extent of surgery
Surgery (total/partial)/Biopsy	72 (55/17)/4	101 (NA/NA)/1	57 (NA/NA)/2
Adjuvant Treatments
RT + TMZ/RT	77/0	71/31	32/27
BVZ/non‐BVZ/UN	29/32/16	NA	NA
Molecular factors
MGMT methylation status
Methylated/Unmethylated	26/51	37/65	26/33
Gene expression subtype
P/N/C/M	18/6/24/27	20/13/37/30	8/4/17/20
TCGA methylation clusters
Clusters 2/3	29/48	35/67	23/36

KPS, Karnofsky performance score; NA, not available; RT, radiotherapy; TMZ, temozolomide; UN, unknown.

^aKPS was available for only a small subset of patients from TCGA cohort.