Table 4.
PANTHER analysis for predicted target genes
| Terms | Target gene | Expected gene Nr | Fold enrichment | P value |
|---|---|---|---|---|
| PANTHER GO‐slim molecular function | ||||
| MAP kinase activity | 17 | 5.04 | 3.38 | 0.028 |
| →Protein serine/threonine kinase activity | 44 | 20.45 | 2.15 | 0.005 |
| →Protein kinase activity | 80 | 38.61 | 2.07 | <0.001 |
| →Catalytic activity, acting on a protein | 170 | 99.8 | 1.7 | <0.001 |
| →Catalytic activity | 396 | 324.05 | 1.22 | 0.012 |
| Ubiquitin‐like protein transferase activity | 45 | 22.2 | 2.03 | 0.017 |
| RNA polymerase II transcription factor activity, sequence‐specific DNA binding | 56 | 27.85 | 2.01 | 0.002 |
| →DNA‐binding transcription factor activity | 125 | 75 | 1.67 | <0.001 |
| →Transcription regulator activity | 140 | 83.93 | 1.67 | <0.001 |
| DNA binding | 92 | 56.39 | 1.63 | 0.008 |
| →Nucleic acid binding | 193 | 125.21 | 1.54 | <0.001 |
| →Binding | 509 | 404.85 | 1.26 | <0.001 |
| →Organic cyclic compound binding | 196 | 129.71 | 1.51 | <0.001 |
| Unclassified | 738 | 859.06 | 0.86 | 0 |
| PANTHER GO‐slim biological process | ||||
| Regulation of transcription by RNA polymerase II | 52 | 26.71 | 1.95 | 0.044 |
| →Regulation of transcription, DNA‐templated | 55 | 28.84 | 1.91 | 0.038 |
| →regulation of biological process | 390 | 287.8 | 1.36 | <0.001 |
| →Biological regulation | 420 | 312.6 | 1.34 | <0.001 |
| →Regulation of metabolic process | 182 | 106.9 | 1.7 | <0.001 |
| →Regulation of macromolecule metabolic process | 157 | 91.18 | 1.72 | <0.001 |
| →Regulation of gene expression | 114 | 64.47 | 1.77 | <0.001 |
| Transcription by RNA polymerase II | 128 | 68.59 | 1.87 | <0.001 |
| →Transcription, DNA‐templated | 162 | 93.7 | 1.73 | <0.001 |
| →Cellular macromolecule biosynthetic process | 186 | 118.42 | 1.57 | <0.001 |
| →Metabolic process | 460 | 364.94 | 1.26 | <0.001 |
| →Biosynthetic process | 192 | 123.53 | 1.55 | <0.001 |
| →Macromolecule biosynthetic process | 188 | 120.02 | 1.57 | <0.001 |
| →Organic substance biosynthetic process | 192 | 123.07 | 1.56 | <0.001 |
| Cellular protein modification process | 84 | 50.21 | 1.67 | 0.032 |
| →Protein modification process | 84 | 50.36 | 1.67 | 0.033 |
| Unclassified | 670 | 820.69 | 0.82 | 0 |
| PANTHER GO‐slim cellular component | ||||
| Nuclear chromatin | 66 | 36.62 | 1.8 | 0.008 |
| →intracellular part | 398 | 311.92 | 1.28 | <0.001 |
| →cell part | 540 | 448.19 | 1.2 | 0.001 |
| →cell | 544 | 450.25 | 1.21 | <0.001 |
| Unclassified | 809 | 909.65 | 0.89 | 0 |
| Extracellular space | 22 | 56.31 | 0.39 | <0.001 |
| →Extracellular region part | 28 | 62.41 | 0.45 | 0.001 |
| →Extracellular region | 35 | 70.2 | 0.5 | 0.002 |
| PANTHER pathways | ||||
| EGF receptor signaling pathway | 29 | 10.15 | 2.86 | 0.001 |
| Cadherin signaling pathway | 33 | 11.98 | 2.75 | <0.001 |
| FGF signaling pathway | 24 | 9.16 | 2.62 | 0.015 |
| CCKR signaling map | 31 | 13.2 | 2.35 | 0.008 |
| PDGF signaling pathway | 26 | 11.37 | 2.29 | 0.046 |
| Wnt signaling pathway | 52 | 23.73 | 2.19 | <0.001 |
| Unclassified | 1304 | 1404.08 | 0.93 | 0 |