Figure 2.

DMF specifically depleted memory T‐ and B‐lymphocyte subpopulations in  NEDA patients. Representation of percentages (%) of central memory (CM), effector memory (EM), naïve, and terminally differentiated RA (EMRA) CD4⁺ and CD8⁺ T lymphocytes from patients with no evidence of disease activity (NEDA) (A, C) and patients with ongoing disease activity (ODA) (B, D), before the treatment (Baseline) and after 1, 3, 6, and 12 months of follow‐up. In addition, % of preswitched memory, class‐switched, naïve, and double negative B lymphocytes from NEDA and ODA patients (E, F) was analyzed before and after treatment. Data are expressed as mean of each lymphocyte subpopulation of NEDA (n = 15) and ODA (n = 6) patients. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001