Figure 2.

Genome-wide CNV Associations for Acute Coronary Artery Disease (CAD)

(A and B) Manhattan plots for (A) genome-wide association of common copy-number variants and (B) genome-wide burden test of rare variants for genes with at least ten individuals observed with CNVs.

(C) Locus inset of 9p23 CNV and summary statistics from GWAS of coronary artery disease using variants imputed on the same study population used in the CNV analysis. Variants are colored by marker LD with lead regional GWAS SNPs (rs145879274) from the analysis. This marker is highly stratified by continental ancestry and does not show significant correlation with any other variant in the region.

(D) Quantile-quantile plots for genome-wide summary statistics from CNV associations.