Table 3.

Area under the ROC curve of plasma biomarkers for distinguishing between iARDS and dARDS

Biomarkers	AUC	95% CI
Coagulation
Platelet count	0.77	0.65–0.86
Immature platelet fraction	0.69	0.54–0.81
PT-INR	0.61	0.49–0.73
FDP	0.51	0.38–0.63
TAT	0.72	0.59–0.82
PIC	0.69	0.56–0.80
PAI-1	0.89	0.74–0.96
Protein C	0.86	0.76–0.93
Infection/inflammation
PCT	0.89	0.79–0.96
CRP	0.65	0.52–0.76
Alveolar epithelial injury
SP-D	0.88	0.77–0.94
KL-6	0.90	0.79–0.95

AUC area under the receiver characteristics curve, CI confidence interval, PT-INR prothrombin time–international normalized ratio, FDP fibrin degradation products, TAT thrombin–antithrombin complex, PIC plasmin–α₂-plasmin inhibitor complex, PAI-1 plasminogen activator inhibitor-1, PCT procalcitonin, CRP C-reactive protein, SP surfactant protein