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. 2019 Aug 12;10:885. doi: 10.3389/fphar.2019.00885

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Copyright © 2019 Alasmari, Crotty Alexander, Hammad, Bojanowski, Moshensky and Sari

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of inhalation of E-cigarette vapor (E-CIG) for 6 months on dopamine concentrations in the frontal cortex (FC) and striatum (STR) in male C57BL/6 mice. (A) Peaks of dopamine in the FC in air and E-CIG groups. (B) Independent t-test analysis did not show any significant alterations in dopamine concentration in the FC between control and E-CIG groups. (C) Peaks of dopamine in the STR for air and E-CIG groups. (D) Independent t-test analysis revealed a significant reduction in dopamine concentration in the STR in E-CIG vapor–exposed group as compared to air controls. Data are reported as mean ± SEM (*p < 0.05, ns; not significant), (n = 5 for each group), (X-axis, retention time [minutes], Y-axis, response).