Table 6.
Representative analysis of main cell populations in patients
| Patient ID | TCD4 | TCD8 | NK | ||||||
|---|---|---|---|---|---|---|---|---|---|
| B | 1 w | 1 m | B | 1 w | 1 m | B | 1 w | 1 m | |
| 3 | 24.8 | 20.0 | 27.4 | 20.1 | 20.1 | 27.2 | 8.9 | – | 10.4 |
| 5 | 8.0 | 3.4 | 5.6 | 3.9 | 2.6 | 2.6 | 19.9 | 13.5 | 23.4 |
| 8 | – | 12.9 | 14.1 | – | 8.5 | 10.2 | – | 3.1 | 6.6 |
| 10 | 13.4 | 13.6 | 9.6 | 8.5 | 18.7 | 17.5 | 7.3 | – | – |
| 14 | 30.8 | 35.7 | 36.9 | 32.3 | 31.0 | 28.6 | 5.0 | 3.7 | 3.1 |
| 15 | 12.6 | 9.2 | 79.9 | 7.8 | 8.0 | 7.3 | 16.3 | 12.6 | 13.9 |
| 18 | 12.9 | 11.6 | 13.6 | 4.1 | 8.8 | 5.7 | 11.1 | 3.6 | 10.3 |
| 21 | 13.8 | 17.9 | 14.6 | 3.4 | 4.1 | 4.0 | 17.6 | 15.9 | 21.7 |
| 24 | 49.0 | 32.3 | 51.0 | 6.0 | 3.7 | 6.1 | 6.9 | 3.3 | 5.7 |
| 26 | 15.0 | 16.6 | 14.1 | 15.9 | 16.3 | 13.7 | 20.9 | 21.0 | 16.1 |
| 27 | 22.4 | 19.1 | 8.9 | 9.3 | 11.5 | 3.8 | 4.8 | 10.3 | 6.4 |
| 28 | 48.2 | 36.4 | 41.9 | 5.2 | 6.5 | 5.6 | – | 8.6 | 6.5 |
| 29 | 0.4 | 0.6 | 0.6 | 1.2 | 2.1 | 1.7 | 1.6 | 2.2 | 1.7 |
| 30 | 22.6 | 22.9 | 23.7 | 8.6 | 7.1 | 14.3 | 6.3 | 6.0 | 6.4 |
| Patient ID | MDSC | Tem | Tcm | ||||||
|---|---|---|---|---|---|---|---|---|---|
| B | 1 w | 1 m | B | 1 w | 1 m | B | 1 w | 1 m | |
| 3 | 0.6 | 0.6 | – | 1.8 | 2.1 | 2.9 | 1.5 | 1.6 | 2.3 |
| 5 | 1.8 | 2.3 | 2.3 | 0.5 | 0.3 | 0.5 | 0.5 | 0.3 | 0.3 |
| 8 | – | 2.7 | 2.1 | – | 3.6 | 3.7 | – | 0.3 | 0.3 |
| 10 | 1.6 | – | 2.0 | 0.5 | – | 2.3 | 0.2 | – | 0.4 |
| 14 | 0.5 | 0.8 | 0.3 | 3.8 | 3.5 | 3.1 | 19.8 | 17.1 | 14.8 |
| 15 | 1.1 | 2.0 | 1.2 | 2.1 | 2.7 | 2.3 | 0.5 | 0.6 | 0.8 |
| 18 | 2.0 | 1.9 | 3.5 | 0.9 | 3.2 | 1.8 | 0.0 | 0.1 | 0.0 |
| 21 | 1.7 | 2.4 | 1.7 | 1.2 | 1.3 | 1.4 | 0.0 | 0.1 | 0.1 |
| 24 | 0.3 | 0.9 | 0.9 | 0.5 | 0.4 | 0.4 | 1.2 | 0.7 | 1.1 |
| 26 | 0.5 | 0.7 | 1.1 | 2.3 | 2.6 | 2.2 | 0.1 | 0.2 | 0.2 |
| 27 | 1.2 | 0.6 | 0.4 | 3.4 | 3.3 | 1.2 | 0.1 | 0.1 | 0.1 |
| 28 | 0.5 | 0.7 | 0.4 | 3.3 | 4.2 | 4.3 | 0.2 | 0.2 | 0.2 |
| 29 | 9.0 | 5.1 | 6.0 | 0.1 | 0.2 | 0.2 | 0.1 | 0.2 | 0.1 |
| 30 | 0.3 | 0.2 | 0.2 | 3.0 | 2.0 | 4.3 | 0.5 | 0.5 | 0.5 |
Patients’ blood samples were analyzed by flow cytometry at different time-points after treatment: B: baseline; 1 w: 1 week post treatment; 1 m: 1 month post treatment. Data represent percent of total PBMC. Cell populations: TCD4 (CD3+ CD4 +), TCD8 (CD3+ CD8 +), NK (CD3−CD56 +), MDSC (Lin-DR-CD3 + CD116+), Tem (CD3+ CD8+ CD45RA-CD197−), Tcm (CD3+ CD8+ CD45RA−CD197+)