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. 2019 Aug 1;105(2):334–350. doi: 10.1016/j.ajhg.2019.06.012

Figure 1.

Figure 1

Design of the Present Study

(A) Input GWAS studies used for ASSET analysis.

(B) Definition of concordant and discordant SNP subsets. Concordant SNPs have alleles that demonstrate negative effects on cognitive ability, educational attainment, and schizophrenia risk (i.e., increased schizophrenia risk, reverse-coded for consistency). Discordant SNPs have alleles that demonstrate paradoxical effects on educational attainment and schizophrenia (i.e., higher educational attainment and increased schizophrenia risk, reverse-coded). The Y axes on the forest plots represent different input summary statistics for cognition, education, and schizophrenia.