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. 2019 Jul 12;17:626–635. doi: 10.1016/j.omtn.2019.06.024

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© 2019 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Off-Target Detection of the Edited Human 3PN Zygotes at Predicted Sites

(A) The off-target analysis of the 387 site in human 3PN zygotes. Left: the sequence information of 387 sgRNA and predicted off-target sites; mismatches are highlighted in white, and PAM sequences are highlighted in gray. Right: the frequency of C-to-T conversion at predicted off-target sites. (B) The off-target analysis of the 383 site in human 3PN zygotes. Left: the sequence information of 383 sgRNA and predicted off-target sites; mismatches are highlighted in white, and PAM sequences are highlighted in gray. Right: the frequency of C-to-T conversion at predicted off-target sites.