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. Author manuscript; available in PMC: 2019 Aug 19.
Published in final edited form as: Biomacromolecules. 2017 Sep 14;18(10):3131–3142. doi: 10.1021/acs.biomac.7b00781

Table 1.

Molecular weights, hydrodynamic diameters, and calculated diffusivities for proteins used in the cocktail approach.

Protein Molecular
Weight		 Hydrodynamic
Diameter		 Diffusivity in
Water (x10−8
cm2/s)		 Diffusivity in
Hydrogel (x10−8
cm2/s)
Aprotinin 7 kDa 3.0 nm81 161 24.1 ± 3.8
Myoglobin 17 kDa 3.9 nm75 124 9.4*
Lactoferrin 77 kDa 6.1 nm75 79 2.8 ± 0.1
BSA 66 kDa 7.2 nm75 67 1.9 ± 0.5
Thyroglobulin 670 kDa 17.2 nm
(Manufacturer)		 28 < 0.1**
*

Represents an average effective diffusivity (De) for n=2; variability in the release profile for one sample led to a poor fit assuming 1-D Fickian diffusion, and a De for that sample could not be appropriately determined and was excluded from the average.

**

Diffusion out of the hydrogel is limited and negligible over the time scale of the experiment.