Table 2.
Summary of experimented A. hydrophila fish vaccines in terms of antigenic entity used, fish models, route of administration, and reported efficacy.
| Antigenic entity | Model fish specie | Route of administration | Reported efficacy | Reference |
|---|---|---|---|---|
| Lipopolysaccharide (LPS) and Outer Membrane Protein (OMP) |
Grass Carp (Ctenopharyngodon idella) |
Injected intraperitoneally | RPS 83.3, 72.2 | [9] |
| Recombinant outer membrane protein R (rOmpR) |
Rohu (Labeo rohita) | Injected intraperitoneally | RPS 52 | [6] |
| Outer membrane protein (Omp-G) | eels (Anguilla anguilla) | injected intraperitoneally | RPS 50-75 | [18] |
| Outer membrane proteins (OmpA1, Tdr, and TbpA) | Channel catfish (Ictalurus punctatus) | intraperitoneally (IP) injected |
RPS 98.59, 95.59, and 47.89 |
[7] |
| Outer Membrane Protein (OMP) | Goldfish (Carassius auratus | Injected intraperitoneally | 50% | [11] |
| Outer Membrane Protein (OMP) | American eel (Anguilla rostrata) |
Injected intraperitoneally | RPS 50% | [21] |
| Outer membrane protein 48 (Omp48) | Rohu (Labeo rohita) | intramuscularly | RPS 69 | [22] |
| Outer membrane proteins, (Aha1 and OmpW) | common carp | injected intraperitoneally | RPS 67 and 80 | [19] |
| OmpW PLGA | Rohu (Labeo rohita) | orally administered | RPS 37.33- 79.99 | [26] |
| Omp38 | Chinese breams | intraperitoneally immunized | RPS 50.00-57.14 | [20] |
| The iron-regulated outer membrane protein (OMP) | zebrafish, | injected intramuscularly | RPS 63.4-68.6 | [24] |
| Live recombinant Lactococcus lactis vaccine expressing aerolysin genes D1 and D4 |
Tilapia (Oreochromis niloticus) | intraperitoneal injection oral feeding |
RPS 55–82 RPS 70–100 |
[14] |
| Recombinant Aeromonas hydrophila vaccine (Aera) | grass carp | bath immunization | - | [23] |
| Recombinant protein aerA | Grass carp | bath immunization intramuscular injection |
RPS 84.9 RPS 79.6 |
[17] |
| N-acyl Homoserine 1 Lactonase | Zebrafish | oral administration | - | [15] |
| Fimbrial Proteins (FimA, Fim, FimMrfG, and FimOM) | Channel Catfish | injected intraperitoneally | RPS 59.83, 95.41, 85.72, and 75.01 | [13] |
| Maltoporin (46 kD) | European eel (Anguilla anguilla) | intraperitoneal injected |
RPS 62.5-100 | [12] |
| Glycoprotein-based native-subunit | Rainbow Trout (Oncorhynchus mykiss) |
Immersion injected intraperitoneally |
68.0% | [10] |
| Recombinant S-layer protein vaccine |
common carp | vaccinated intraperitoneally | RPS 56-87 | [16] |
| G-protein coupled receptor 18 (GPR18) | channel catfish | intraperitoneally injected | 50-100% | [29] |
| Recombinant Hemolysin Co-regulated Protein (Hcp) | Common carp (Cyprinus carpio) | injected intraperitoneally | RPS 46.67 | [25] |
| DNA vaccine (naked plasmid DNA) | grass carp | injected intramuscularly | RPS 68.9 | [27] |
| Apolipoprotein A1 plasmid DNA | channel catfish | intraperitoneally injected |
100% | [28] |