Table 3.
Comparison of minor allele frequencies of BIRC5 polymorphisms between breast cancer patients and healthy control samples. Nucleotide changes are named according to the literature.
| gene region | SNP ID number | nucleotide change | minor allele frequency controls (n/N, %)∗ | minor allele frequency BC samples (n/N, %)∗ | p (for allele frequencies) |
|---|---|---|---|---|---|
| promoter | rs3764383 | c.-1547C>T∗∗ | 37/148 (25.0) | 16/52 (30.8) | 0.466 |
|
| |||||
| promoter | rs8073903 | c.-644T>C | 49/148 (33.1) | 18/52 (34.6) | 0.865 |
|
| |||||
| promoter | rs8073069 | c.-625G>C | 33/148 (22.3) | 13/52 (25.0) | 0.704 |
|
| |||||
| promoter | rs17878731 | c.-267G>A | 1/148 (0.7) | 1/52 (1.9) | 0.453 |
|
| |||||
| promoter | rs17878467 | c.-241C>T | 16/148 (10.8) | 6/52 (11.5) | 1.000 |
|
| |||||
| promoter | rs17887126 | c.-235G>A | 2/148 (1.3) | 0/52 (0) | |
|
| |||||
| 5'UTR | rs9904341 | c.-31G>C | 55/148 (37.2) | 18/52 (34.6) | 0.867 |
|
| |||||
| intron 2 | rs4789551 | c.221+209T>C | 7/148 (4.7) | 1/52 (1.9) | 0.683 |
|
| |||||
| exon 4 | rs2071214 | c.9194G>A∗∗∗ | 5/148 (3.4) | 1/52 (1.9) | 1.000 |
|
| |||||
| 3'UTR | rs17885521 | c.9288G>C | 3/148 (2.0) | 1/52 (1.9) | 1.000 |
|
| |||||
| 3'UTR | rs17882627 | c.9342G>A | 2/148 (1.3) | 2/52 (3.8) | 0.278 |
|
| |||||
| 3'UTR | rs2239680 | c.9386T>C | 34/148 (23.0) | 14/52 (26.9) | 0.575 |
|
| |||||
| 3'UTR | rs17882139 | c.9387_9388insAA | 3/148 (2.0) | 2/52 (3.8) | 0.606 |
|
| |||||
| 3'UTR | rs1042489 | c.9809T>C | 53/148 (35.8) | 18/52 (34.6) | 1.000 |
|
| |||||
| 3'UTR | rs2661694 | c.10611C>A | 38/148 (25.7) | 11/52 (21.1) | 0.578 |
∗ n – number of minor alleles, N – number of analyzed alleles
∗∗C is the minor allele
∗∗∗G is the minor allele.