Table 4.
Association of genotype and allele frequencies of polymorphisms with age of onset.
| polymorphism | mean±SD (years) | p-value | ||
|---|---|---|---|---|
| c.-1547C>T∗ | genotype | CC | 62.3±6.5 | 0.054 |
| CT | 55.8±8.1 | |||
| TT | 49.0±10.1 | |||
| allele | C | 58.3±7.9 | 0.011 | |
| T | 50.9±9.8 | |||
|
| ||||
| c.-644T>C | genotype | TT | 59.4±8.2 | 0.006 |
| TC | 50.7±8.6 | |||
| CC | 39.0±2.8 | |||
| allele | T | 55.8±9.2 | 0.006 | |
| C | 48.1±9.1 | |||
|
| ||||
| c.-241C>T | genotype | CC | 54.7±10.0 | 0.143 |
| CT | 49.0±4.5 | |||
| TT | 37.0±0.0 | |||
| allele | C | 54.2±9.6 | 0.029 | |
| T | 45.0±7.1 | |||
|
| ||||
| c.9386T>C | genotype | TT | 49.1±9.3 | 0.029 |
| TC | 57.4±8.4 | |||
| CC | 62.3±6.5 | |||
| allele | T | 50.8±9.6 | 0.004 | |
| C | 59.5±7.6 | |||
|
| ||||
| c.9809T>C | genotype | TT | 59.4±8.2 | 0.006 |
| TC | 50.7±8.6 | |||
| CC | 39.0±2.8 | |||
| allele | T | 55.8±9.2 | 0.006 | |
| C | 48.1±9.1 | |||
∗ C is the minor allele.