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. 2019 Aug 12;9:715. doi: 10.3389/fonc.2019.00715

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Copyright © 2019 Van Der Weijst, Lievens, Schrauwen and Surmont.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Overview of different therapies incorporated in clinical trials over the last 10 years. *Based on the year of HRQoL publication; CT, chemotherapy vs. chemotherapy or placebo; TT, targeted therapy vs. targeted therapy or placebo; CT vs. TT, chemotherapy vs. targeted therapy; sequential: sequential therapy consisting of both targeted and chemotherapy; CT vs. IM, chemotherapy vs. immunotherapy. (B) Overview of clinical trials with/without significant differences in HRQoL between therapy arms over the last 10 years. *Based on the year of HRQoL publication; MCID, meaningful clinically important difference.