Table 8.

Data summary of patients with TAO and lymphohematopoietic system involvement

No	Year	Authors	The number of patients	Age	Chief complaint	Duration of disease (amputation)	Smoking status	How to diagnose the current disease	Suggested treatment	The outcome of treatment
1	2016	Akbarin et al (Iran)76	26 (26 CBC and serum samples out of 37 documents and banked samples)	27–49 years	40±7 years	Unknown	Mean cigarette consumption was 397.77 packs per year (minimum 60 packs and maximum1110 packs per year	Anemia defined as Hgb <13.5 g/dL for males which could not be explained by anemia of chronic disease or iron deficiency according to several indices including MCV, MCH, LDH, ALT, AST	Unknown	Unknown
2	2010	Takaoka et al (Japan)77	1	46 years	One month history of sharp rest pain in right calf and ischemic ulcer between the third and fourth toes of his right foot and lymphadenopathy in bilateral inguinal region	TAO diagnosis according to clinical manifestation and angiography pattern of lower limbs	About 10 cigarettes per day for 25 years	Excision biopsy of left inguinal nodule Histology examination demonstrated hyperplasia of lymphoid follicles with massive infiltration of eosinophil without malignancy CBC demonstrated eosinophilia	Prednisolon 40 mg per day	The eosinophilia, the ulcer and rest pain of right foot improved quickly
3	1971	Ward et al (Colorado, USA)78	1 (1 out of 31 cases of anemia suffering from chronic disease)	Unknown	Unknown	Unknown	Unknown	Laboratory tests Low hematocrit, normal iron level, high iron saturation, increased bone marrow iron with normal erythropoietin	Unknown	Unknown