Effect of NanoSOD on metabolic variables in mice exhibiting diet-induced obesity. Total cholesterol (A), free fatty acids (B), triglycerides (C), fasting blood glucose (D), insulin (E), and insulin resistance via HOMA-IR (F) were recorded. Values are expressed as mean ± SEM of 12-14 samples in each group. *P<0.05, **P<0.01, & ****P<0.0001 vs CD; ^P<0.05 vs HF. CD, chow diet; HF, high fat diet; and Nano, NanoSOD.