Figure 6.

Expression of PAR-1 drives tumor growth in the pancreas microenvironment, resulting in poor host survival. A, KPC2 WT or KPC2 Par-1^KO/Tg cells were injected into the pancreas and mice were treated ± Dox (N = 12 mice per group). Pancreas tumors were harvested at 21 days postsurgery.B, Representative examples of isolated tumors from the pancreas of mice 21 days postsurgery. Asterisk indicates one of only two tumors generated out of a cohort of 12 mice from the Par-1^KO/Tg cells in the absence of Dox. The remaining 10 animals failed to develop visible tumors within the 21-day period. C, Survival study following orthotopic pancreas injection of KPC2 WT vs. KPC2 Par-1^KO1 cells (N = 12 mice per group). Median survival times are indicated for each study (red dot). Scale bar, 2 mm. ****, P < 0.0001; n.s., not significant.