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Main toxicities of anlotinib treatment
| Toxicity | Grades 1–2 | Grade 3 |
|---|---|---|
| Hand-foot syndrome | 15 (25.9%) | 2 (3.4%) |
| Hypertension | 9 (15.5%) | 1 (1.7%) |
| Fatigue | 7 (12.1%) | 1 (1.7%) |
| Anorexia | 6 (10.3%) | 0 |
| Diarrhea | 6 (10.3%) | 0 |
| Oral mucositis | 6 (10.3%) | 0 |
| Liver dysfunction | 5 (8.6%) | 0 |
| TSH elevation | 1 (1.7%) | 0 |
| Proteinuria | 1 (1.7%) | 0 |
| Electrocardiographic abnormality | 1 (1.7%) | 0 |
Abbreviation: TSH, thyroid stimulating hormone.
