Table 3.
Body shape trajectories and the risk of MM among participants in the NHS and HPFS
| NHS |
HPFS |
Pooled*,† | |||||
|---|---|---|---|---|---|---|---|
| Category | Cases | Person-years | HR (95% CI)‡ | Cases | Person-years | HR (95% CI)‡ | HR (95% CI)‡ |
| Lean-stable | 58 | 673 466 | 1 | 30 | 182 785 | 1 | 1 |
| Lean-increase | 71 | 799 581 | 1.06 (0.75 to 1.50) | 72 | 352 591 | 1.36 (0.89 to 2.10) | 1.17 (0.89 to 1.53) |
| Medium-stable | 104 | 1 093 971 | 1.20 (0.87 to 1.65) | 38 | 181 441 | 1.39 (0.85 to 2.26) | 1.27 (0.97 to 1.66) |
| Medium-increase | 86 | 829 720 | 1.51 (1.08 to 2.12) | 36 | 167 157 | 1.90 (1.16 to 3.13) | 1.62 (1.22 to 2.14) |
*
P values for heterogeneity by sex (cohort) were all at least .37. CI = confidence interval; HPFS = Health Professionals Follow-Up Study; HR = hazard ratio; MM = multiple myeloma; NHS = Nurses’ Health Study.
†
Pooled models were additionally adjusted for sex (cohort).
‡
Hazard ratios and 95% confidence intervals were calculated in Cox proportional-hazards models stratified by age and calendar period of follow-up and adjusted for height.