Table 1.
Demographics and characteristics of children in progression to CP.
| Variables | Count/Sample Size (%) |
|---|---|
| (n=442) | |
| Gender (male) | 191 (43.2) |
| Ethnicity (Hispanic) | 95/408 (23.3) |
| Family history CP, any blood relative | 87/369 (23.6) |
| PRSS1 variants | 91/303 (30.0) |
| CFTR variants | 94/304 (30.9) |
| SPINK1 variants | 94/304 (30.9) |
| Obstructive factors* | 130/437 (29.8) |
| Toxic-metabolic factors** | 101/403 (25.1) |
| Age at first acute attack | (n=419) |
| Median (IQR) | 9.0 (4.8–12.9) |
| <6 years of age at first attack | 147/419 (35.1) |
| Duration of disease, years | 2.1 (0.8–4.5) |
Table showing demographics and clinical characteristics of children with progression to chronic pancreatitis. IQR=Interquartile range= (25th-75th percentile); CP: chronic pancreatitis; CFTR: cystic fibrosis transmembrane conductance regulator; PRSS1: cationic trypsinogen; SPINK1: pancreatic secretory trypsin inhibitor
*
at least 1 of the following present-- gallstones, pancreaticobiliary malunion, choledochal cyst, functional pancreatic sphincter dysfunction, pancreas divisum or annular pancreas
**
at least 1 of the following present-- alcohol, smoking (active or passive), hypertriglyceridemia, hypercalcemia, renal failure, medication usage