3. QoL results.

Domain	Time	Treatment group medians (IQR)	Statistical significance in change from baseline	Control group medians (IQR)	Statistical significance in change from baseline
Physical	baseline	80.50 (54.1 to 88.88)		72.21 (56.94 to 88.80)
	post‐intervention	83.30 (62.48 to 93.74)		83.30 (51.39 to 95.46)
	follow up	83.30 (70.8 to 95.83)		91.66 (75.00 to 100.00)
Emotional	baseline	81.65 (71.46 to 87.50)		84.97 (60.63 to 92.88)
	post‐intervention	83.30 (73.73 to 92.91)	P = 0.031	80.00 (64.58 to 91.65)
	follow up	75.00 (66.60 to 91.60)		83.30 (66.66 to 100.00)
Social	baseline	71.42 (57.10 to 79.76)		71.80 (61.90 to 85.70)
	post‐intervention	71.81 (62.48 to 83.30)		66.60 (54.50 to 76.17)	P = 0.044
	follow up	71.42 (66.6 to 85.71)		72.20 (52.38 to 90.47)
Body image	baseline	83.29 (66.62 to 100.00)		77.77 (69.42 to 100.00)
	post‐intervention	94.44 (66.66 to 100.00)		83.25 (66.66 to 97.22)
	follow up	100.00 (66.60 to 100.00)		88.80 (77.70 to 100.00)
Eating	baseline	100.00 (55.55 to 100.00)		100.00 (66.62 to 100.00)
	post‐intervention	88.88 (66.60 to 100.00)		83.29 (66.62 to 100.00)
	follow up	88.88 (66.60 to 100.00)		100.00 (88.80 to 100.00)
Treatment burden	baseline	66.63 (55.50 to 77.77)		61.08 (47.21 to 77.70)
	post‐intervention	77.74 (66.62 to 97.20)	P = 0.014	66.60 (44.44 to 94.44)	P = 0.026
	follow up	77.70 (55.50 to 100.00)	P = 0.031	66.60 (44.40 to 77.77)
Respiratory symptoms	baseline	66.60 (52.08 to 77.03)		58.30 (50.00 to 2.92)
	post‐intervention	80.54 (75.00 to 88.80)	P = 0.001	79.15 (60.38 to 87.43)	P = 0.002
	follow up	83.30 (72.20 to 91.66)	P = 0.016	83.30 (66.60 to 88.80)	P = 0.013
Digestion	baseline	83.33 (66.62 to 100.00)		94.40 (66.60 to 100.00)
	post‐intervention	100.00 (88.88 to 100.00)	P = 0.024	100.00 (66.62 to 100.00)
	follow up	100.00 (88.80 to 100.00)		100.00 (66.66 to 100.00)
Vitality	baseline	45.80 (33.32 to 54.17)		49.95 (33.32 to 64.55)
	post‐intervention	41.63 (33.30 to 66.62)		66.65 (45.83 to 91.60)	P = 0.043
	follow up	50.00 (41.67 to 58.33)		75.00 (49.95 to 85.40)
Health perception	baseline	61.05 (38.86 to 80.50)		44.42 (30.53 to 80.48)
	post‐intervention	61.05 (47.18 to 83.28)		77.70 (61.06 to 100.00)
	follow up	55.50 (33.31 to 83.29)		88.80 (58.32 to 94.40)
Role	baseline	58.33 (47.90 to 77.08)		62.47 (54.13 to 87.48)
	post‐intervention	58.30 (39.53 to 66.62)		66.63 (58.30 to 77.08)
	follow up	75.00 (58.33 to 75.00)		83.30 (49.95 to 95.83)
Weight	baseline	100.00 (0.00 to 100.00)		33.30 (24.98 to 50.00)
	post‐intervention	100.00 (24.98 to 100.00)		66.60 (33.32 to 100.00)
	follow up	100.00 (0.00 to 100.00)		66.60 (33.31 to 100.00)

IQR: inter‐quartile range