Cameron 1990.

Methods	Single‐centre with parallel‐group design MBL over 2 cycles assessed in 102 women with a subjective complaint of HMB. 20 women refused to collect sanitary pads, 10 women had anovulatory cycles and 40 women had MBL < 80 mL/cycle. The remaining women (n = 32) were randomized to treatment arms. No power calculation or ITT analysis No source of funding stated
Participants	Patients aged 21‐51 years recruited from the Outpatient Department, Royal Infirmary, Edinburgh, UK Inclusion criteria: MBL > 80 mL/cycle over 2 cycles measured by the alkaline haematin method Exclusions: organic disease non‐ovulatory cycles non compliance with collecting pads
Interventions	NET 5 mg twice daily on days 19‐26 of the menstrual cycle Mefenamic acid 500 mg 3 times/day on days 1‐5 of the menstrual cycle Duration over 2 cycles
Outcomes	MBL Number of days bleeding Cycle length Side effects Patient compliance
Notes	Original data provided by the lead author
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Randomization technique centralized and controlled by pharmacy
Allocation concealment (selection bias)	Low risk	Adequate
Blinding of participants and personnel (performance bias) PBAC, satisfaction, Adverse effect, response to treatment, bleeding	High risk	No blinding, lack of blinding likely to influence outcomes
Blinding of participants and personnel (performance bias) Haematin alkaline	Low risk	No blinding, lack of blinding unlikely to influence outcomes
Blinding of outcome assessment (detection bias) PBAC, satisfaction, Adverse effect, response to treatment	High risk	No blinding, lack of blinding likely to influence outcomes
Blinding of outcome assessment (detection bias) Haematin Alkaline	Low risk	No blinding, lack of blinding unlikely to influence outcomes
Incomplete outcome data (attrition bias) All outcomes	Low risk	No withdrawals/exclusions reported
Selective reporting (reporting bias)	Unclear risk	No protocol available
Other bias	Low risk	Similar at baseline: groups balanced on baseline Disclaimer: not stated CoI: not stated Source of funding: Not stated