Goshtasebi 2013.

Methods	RCT, with parallel‐group technique Block randomization technique Participants unable to be blinded, given the differences between the regimens
Participants	Country: Iran Number of participants: 90, 19 of whom withdrew by the end of the follow‐up period Age: 20‐45 years old Inclusion criteria: reported regular HMB; BMI 19‐29 Exclusion criteria: “organic cause of HMB”, iron‐deficiency anaemia, previous VTE, history of chronic diseases, history of diseases known to interfere with menstrual bleeding (e.g. fibroids, anticoagulant use, COCP or other hormonal drug use), IUS in situ
Interventions	TXA 500 mg 4 times daily for days 1‐5 of menses MPA 5 mg twice daily, for days 5‐26 of the menstrual cycle
Outcomes	Subjective assessment of MBL, using a modified PBAC (end scores) Serum Hb and ferritin SF‐36 for QoL (Farsi version) HMB questionnaire (Farsi version) Side effects
Notes	Funded by Tarbiat Modares University
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Block randomization
Allocation concealment (selection bias)	Unclear risk	Not reported
Blinding of participants and personnel (performance bias) PBAC, satisfaction, Adverse effect, response to treatment, bleeding	High risk	Unable to blind participants due to different regimens. Potential knowledge of treatment may have influenced the primary outcome of MBL, which was measured by PBAC
Blinding of participants and personnel (performance bias) Haematin alkaline	Unclear risk	Alkaline haematin was not measured.
Blinding of outcome assessment (detection bias) PBAC, satisfaction, Adverse effect, response to treatment	Unclear risk	It is unclear whether or not personnel were blinded
Blinding of outcome assessment (detection bias) Haematin Alkaline	Unclear risk	Alkaline haematin was not measured.
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Significant loss to follow‐up, but similar numbers and reasons for each group 71/90 randomized women (79%) included in analysis
Selective reporting (reporting bias)	Low risk	All prespecified outcomes were reported
Other bias	Low risk	Similar at baseline: groups balanced on baseline Disclaimer: not stated CoI: not stated Source of funding: funded by Tarbiat Modares University