| Study | Reason for exclusion |
|---|---|
| Ali 2018 | This trial compared hyperfractionated versus standard radiotherapy for patients with glioma; more than 70% of participants had glioblastoma |
| Anand 2012 | No comparator arm |
| Archibald 1994 | Wrong comparator arm (healthy controls) |
| Armstrong 2002 | No comparator arm, mixed population |
| Behrend 2014 | Not a study report |
| Brown 2003b | Review article |
| Brown 2009 | Commentary |
| Buglione 2014 | Study of early versus late RT for LGG but only 6 patients had neurocognitive function assessed and neurocognitive scores were not compared between study groups |
| Cairncross 2006 | No neurocognitive outcomes reported |
| Chung 2018 | Paricipants all had glioblastoma |
| Combs 2008 | No neurocognitive outcomes |
| Corn 2009 | Before and after study of different doses of RT with no comparator arm |
| Correa 2008 | Treated patients compared with NAT group included patients who had RT (n = 5), RT plus CT (n = 1) but also CT only (n = 3). Data on participants who had RT are not reported separately from those who only had CT |
| Costello 2004 | Wrong comparator (non‐malignant tumour group) |
| Dai 2011 | No neurocognitive outcomes reported |
| Ding 2017 | No neurocognitive outcomes reported |
| Ediebah 2015 | No neurocognitive outcomes reported |
| Eyre 1993 | No neurocognitive outcomes reported |
| Goda 2017 | No neurocognitive data reported |
| Gregor 1996 | No comparator arm |
| Johannesen 2003 | No neurocognitive outcomes reported; no relevant comparison |
| Karim 2002 | No neurocognitive outcomes reported |
| Klein 2004 | Not a study but a letter to the editor |
| Laack 2005 | A cohort study of 20 adults who received radiotherapy (50.4Gy or 64.8Gy) for LGG. Cognitive function was reported as stable at 3‐year follow up, but findings were not reported separately by treatment group. |
| Lunsford 2001 | Not a study but a letter to the editor |
| Malmstrom 2017 | All received RT; no late effects data |
| MRC 2001 | All received RT; no late effects neurocognitive outcome data reported |
| NCT02655601 | Study examining participants with high‐grade glioma |
| Packer 2002 | Commentary on a paediatric study |
| Repka 2018 | Recruited patients with high‐grade glioma and glioblastoma |
| Satoer 2014 | Wrong intervention and no late neurocognitive outcomes reported |
| Shaw 2006 | No comparator arm |
| Sherman 2016 | Wrong comparator (published normals) |
| Sichez 1996 | Wrong population ‒ mixed HGG population |
| Surma‐aho 2001 | Retrospective study of effects of RT versus no RT but the study groups were highly selected at baseline and so the findings are impossible to interpret with any certainty |
| Taphoorn 1994 | Not a study but a letter to the editor |
| Taylor 1998 | No comparator arm |
| Thomas 2001 | All received RT; no late effects neurocognitive outcomes data reported |
| van den Bent 2006 | No neurocognitive outcome data reported |
| Wheeler 2016 | Mixed HGG population with low numbers with grade 3; all had RT (question was the effect of immunotherapy) |
| Wick 2009 | No long‐term (> 2 years) neurocognitive outcome data reported |
| Williamson 2017 | This study looked at re‐irradiation of patients with recurrent glioma; some had glioblastoma and no neurocognitive outcomes were reported |
| Wirsching 2018 | This trial examined chemoradiotherapy versus radiotherapy alone in elderly patients (ARTE trial). All participants had glioblastoma |
| Zhu 2017 | All participants in this trial had glioblastoma |
Gy = Grays; LGG = low grade glioma; HGG = high grade glioma;nNAT = no adjuvant treatment; RCT = randomised controlled trial; RT= radiotherapy;