Table 4. Prognostic factors for overall survival (OS) in patients with Wilms tumour (N = 4596).

Characteristic		Events	Univariable		Multivariable, age categorized		Multivariable, age linear
			HR (95% CI)	p-value	HR (95% CI)	p-value	HR (95% CI)	p-value
Sex	Female	168	1		1		1
	Male	123	0·84 (0·67–1·06)	0·14	0·85 (0·67–1·07)	0·16	0·84 (0·66–1·06)	0·13
Age at diagnosis, categorized (years)	0–2	31	1		1
	2–4	83	1·96 (1·30–2·96)	0·0014	1·29 (0·85–1·97)	0·23
	4–10	159	3·63 (2·47–5·33)	< 0·0001	1·67 (1·11–2·51)	0·01
	10–18	18	5·16 (2·89–9·23)	< 0·0001	1·87 (1·02–3·44)	0·04
Age at diagnosis, linear (years)		291	1·15 (1·11–1·19)	< 0·0001			1·04 (1–1·08)	0·06
Overall stage	I	56	1		1		1
	II	48	1·69 (1·15–2·49)	0·0076	1·43 (0·97–2·11)	0·07	1·47 (1–2·17)	0·05
	III	76	3·91 (2·77–5·52)	< 0·0001	2·76 (1·93–3·94)	< 0·0001	2·86 (2·01–4·09)	< 0·0001
	IV	111	6·65 (4·82–9·17)	< 0·0001	6·78 (4·82–9·53)	< 0·0001	7·14 (5·09–10·01)	< 0·0001
Histological risk group	Intermediate risk	152	1		1		1
	High risk: diffuse Anaplastic	73	10·13 (7·66–13·40)	< 0·0001	6·91 (5·09–9·39)	< 0·0001	7·38 (5·47–9·95)	< 0·0001
	High risk: blastemal type	57	4·01 (2·96–5·44)	< 0·0001	4·55 (3·31–6·25)	< 0·0001	4·58 (3·33–6·3)	< 0·0001
	Low risk	9	0·86 (0·44–1·68)	0·65	0·53 (0·27–1·05)	0·07	0·55 (0·28–1·09)	0·09
Biopsy	No	192	1		1		1
	Yes	99	1·66 (1·30–2·11)	< 0·0001	1·03 (0·75–1·4)	0·87	1·03 (0·75–1·41)	0·85
Volume at surgery	≤500 ml	201	1		1		1
	>500 ml	90	2·99 (2·33–3·83)	< 0·0001	2·23 (1·7–2·91)	< 0·0001	2·19 (1·67–2·85)	< 0·0001

Univariable and Multivariable Cox regression models of overall survival (OS), stratified by national/regional study group and database (SIOP 93–01 and SIOP 2001), with age categorized and age linear.