Fig. 3.

Diagram showing the simulation procedure for an engineered underdominance system with a constant rate of mutation (m) per gene. Parameter symbols used here are: ε, the relative fitness conferred by a given allele (denoted in the subscripts where M represents a mutated allele); β and ϕ, the numbers of non-mutated copies of construct A and B, respectively; μ and ψ, the number of mutated copies of transgenic constructs A and B, respectively; γ_i, the lethality conferred by a given genotype (i); Ω_i, the overall relative fitness of individuals of genotype i; and $\overline{\Omega },$ the average relative fitness of the entire population.