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Active site of DrDXPS cocrystallized with pyruvate. A three-atom adduct is found in the active site of the DrDXPS structure cocrystallized with pyruvate, suggesting that decarboxylation of the pyruvate has occurred. The C2α-hydroxyl of the enamine forms hydrogen bonds with His-304 and N4′ of ThDP. Tyr-395, Arg-423, and Arg-480, which have been implicated in d-GAP binding (20), are labeled.
