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. 2019 May 16;294(33):12313–12327. doi: 10.1074/jbc.RA118.006074

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© 2019 Ghosh et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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Figure 2. — Cpt1b^M−/− mice substantially remodel lipid handling pathways. IPA of SAGE data was used to develop a global regulator/effector network (A). GSEA was used to generate heatmaps showing that Cpt1b^M−/− (KO; n = 7) mice exhibit up-regulation (red) of pathways involved in fatty acid metabolism (B), glycerolipid metabolism (C), peroxisome metabolism (D), and PPAR signaling (E) versus Cpt1b^fl/fl (WT; n = 8) littermate controls. Peptides related to lipid metabolism were also identified in the proteomics analysis (F). *, p < 0.05. The following key for regulator/effector network is as follows: regulators (top); effectors (bottom); genes (middle); orange (activation/up-regulation); blue (inhibition/down-regulation); solid lines (direct relationship); dashed lines (indirect relationship); ellipse (transcription factor); rectangle (ligand-dependent nuclear receptor); diamond (enzyme); triangle (kinase); trapezoid (transporter); octagon (function); plus (disease).