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Cpt1bM−/− mice up-regulate glucose-handling pathways. GSEA revealed significant remodeling of the insulin-signaling pathway (A). Heatmaps generated via GSEA detailed alterations in glycolysis/gluconeogenesis (B) and pyruvate handling (C) pathways. KEGG painter software was used to generate a metabolic network map showing changes in the glycolysis/gluconeogenesis pathway (D). The following key is used: red (activation/up-regulation); blue (inhibition/down-regulation).
