Table 2.

Local-regional relapse by clinical and pathologic variables

Variable	Univariable		Multivariable
	HR (95% Cl)	P-value	HR (95% Cl)	p-value
Clinical tumor category		0.14	1.00 (ref)	0.024
T0-T2	1.00 (ref)		2.16 (1.10–4.21)
T3-T4	1.60 (0.86–2.93)
Approximated tumor subtype	1.00 (ref)	0	1.00 (ref)	<0.0001
Hormone receptor-positive/HER2-negative	1.50 (0.67–3.33)		2.29 (1.00–5.26)
HER2-positive	3.46 (1.68–7.13)		5.91 (2.80–12.49)
Triple negative
Pathologic CR breast	1.00 (ref)	0.01	1.00 (ref)	0.008
No	0.30 (0.13–0.72)		0.25 (0.09 – 0.70)
Yes
Pathologic tumor category	1.00 (ref)	0.01
T0/Tis	2.47 (0.96 – 6.37)
T1	3.87 (1.49–10.06)
T2	5.41 (1.82–16.10)
T3	12.70 (1.51 –106.85)
T4
Pathologic CR axilla	1.00 (ref)	0.02	1.00 (ref)	0.18
No	0.42 (0.21 – 0.86)		0.56 (0.24–1.30)
Yes
Pathologic nodal category		0.11
N0	1.00 (ref)
N1	2.31 (1.07–4.97)
N2	2.57(1.09–6.06)
N3	2.44 (0.67–8.86)
Pathologic CR breast & axilla	1.00 (ref)	0.02
No	0.32 (0.12–0.81)
Yes
Pathologic CR		0.04
None	1.00 (ref)
Axilla only	0.28 (0.11–0.72)
Breast only	0.66 (0.26–1.69)
Both	0.29 (0.04–2.12)
Breast Surgery Procedure		0.05		0.008
BCS	1.00 (ref)		1.00 (ref)
Mastectomy	0.55 (0.30–1.01)		0.41 (0.21–0.79)
Breast Surgery Procedure		0.16
BCS	1.00 (ref)
Mastectomy & reconstruction	0.64 (0.32–1.27)
Mastectomy no reconstruction	0.46(0.19–1.13)
Radiation therapy		0.1		0.018
Yes	1.00 (ref)		1.00 (ref)
No	1.80 (0.89–3.65)		2.35 (1.15–4.79)
Age (continuous)	1.01 (0.98–1.04)	0.58
Age		0.48
<50	1.00 (ref)
≥50	1.24 (0.68–2.27)
Residual Cancer Burden	1.00 (ref)	0.02
0	1.27 (0.15–10.85)
1	2135 (0.70–6.52)
2	4.52 (1.66–12.35)
3

BCS, breast conserving surgery; CR, complete response; HER2, human epidermal growth factor receptor 2; HR, hazard ratio