. Author manuscript; available in PMC: 2020 Aug 1.

Published in final edited form as: Alzheimers Dement. 2019 Jun 28;15(8):1048–1058. doi: 10.1016/j.jalz.2019.04.014

Table 3.

Highest priority candidate LOAD causal genes: Biomedical and Functional information

Gene name	Gene coordinate	GWAS-SNP (coordinate)	Biomedical/Functional category	Brain expression
CELF1	Chr11: 47,487,489–47,587,121	rs10838725 (Chr11: 47,557,871)	LOAD as a systematic disease, RNA metabolism related	++
SPI1	Chr11: 53,773,960–53,810,230		LOAD as a systematic disease, Neurological and Alzheimer’s associated, HIV related, DNA damage and repair related	++
DDB2	Chr11: 47,236,493–47,260,769		DNA damage and repair related	+
MADD	Chr11: 47,290,712–47,351,582		Neurological and Alzheimer’s associated	++
MTCH2	Chr11: 47,639,858–47,664,206		LOAD as a systematic disease	++
NR1H3	Chr11: 47,269,851–47,290,401		LOAD as a systematic disease	++
PSMC3	Chr11: 47,440,320–47,448,024		DNA damage and repair related	+++
PICALM	Chr11: 85,668,214–85,780,924	rs10792832 (Chr11:85,867,875)	Neurological and Alzheimer’s associated	+++
EED	Chr11: 85,955,586–85,989,855	rs10792832 (Chr11:85,867,875)	HIV related	+
BIN1	Chr2: 127,048,023–127,107,400	rs6733839 (Chr2:127,892,810)	Neurological and Alzheimer’s associated	+++
ERCC3	Chr2: 128,014,866–128,051,752		HIV related, RNA metabolism related, DNA damage and repair related	++
IWS1	Chr2: 128,193,783–128,284,462		HIV related, RNA metabolism related	+