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. Author manuscript; available in PMC: 2020 Jul 7.
Published in final edited form as: Drug Metab Rev. 2019 Jul 7;51(2):162–177. doi: 10.1080/03602532.2019.1632891

Figure 5.

Figure 5.

Oxidation of selegiline to a hydroxylated derivative (R = H -> R = OH) is followed by oxidation of the acetylenic group to a ketene that can be trapped by glutathione (GSH) or can acylate the P450 protein (Protein-XH).