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. Author manuscript; available in PMC: 2020 Jul 7.
Published in final edited form as: Drug Metab Rev. 2019 Jul 7;51(2):162–177. doi: 10.1080/03602532.2019.1632891

Figure 8.

Figure 8.

Cytochrome P450-catalyzed oxidation of efavirenz to a ring-expanded metabolite by a concerted mechanism not involving formation of an oxirene metabolite. The cytochrome P450 activated species is represented as in Figure 6.