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(A) Putative mechanism of glycosidic bond cleavage. Addition of a water molecule or an amine group to the oxocarbenium intermediate would produce an AP site or an iminium crosslink, respectively. (B) Key catalytic residues required for base excision. Carboxylate (aspartate/glutamate) and carboxamide (asparagine/glutamine) functional groups are depicted both as lowest-energy resonance forms (left) and as resonance hybrids (right).
