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. Author manuscript; available in PMC: 2020 Aug 20.
Published in final edited form as: Circulation. 2019 Jun 12;140(8):681–693. doi: 10.1161/CIRCULATIONAHA.119.039642

Figure 3. Loss of local PP1c regulation in the absence of PPP1R3A increases RyR2 and PLN phosphorylation.

Figure 3.

Representative Western blots and corresponding dot plots showing (A and B) increased phosphorylation of RyR2 at S2808 but not at S2814 in Ppp1r3a-KO (KO) mouse atria compared with wild-type (WT) atria. (C and D) increased phosphorylation of PLN at both S16 and T17 in Ppp1r3a-KO mouse atria. Data represent mean±SEM and were analyzed using unpaired 2-tailed Student’s t-test (*P<0.05, **P<0.01 vs. WT).