Table 2. Radiologic criteria for pancreatic IRE assessment 4 .
| CR | PR | SD | PD | |
|---|---|---|---|---|
| Major criteria (1 sufficient for PD) | ||||
| Longest diameter in the axial plane of the soft-tissue component of primary tumor compared with the 1st follow-up scan >3 mo after treatment Metastases (non-nodal) with longest diameter >10 mm |
No residual soft-tissue primary tumor | Decrease >30% | Decrease <30% to increase <20% | Increase >20% |
| No | No | No | Yes | |
| Minor criteria (>2 needed for PD in absence of major criteria) | ||||
| Vessel narrowing (compared with the 1st follow-up scan >3 mo after treatment; >50% diameter reduction; no thrombosis. Biliary stents or endoprosthesis) | No | Yes | ||
| New-onset biliary obstruction (compared with the 1st follow-up scan >3 mo after treatment; no biliodigestive anastomosis, biliary stents or endoprosthesis) | No | Yes | ||
| Enlarging area of diffusion restriction on MRI (compared with the 1st follow-up MRI > 3 mo after treatment) | No | Yes | ||
| New lymph nodes >15 mm short-axis diameter or pathology proven (compared with the 1st follow-up scan > 3 mo after treatment) | No | Yes | ||
| CA 19.9 increase >100% (and >74 U/mL) without signs for pancreatitis or biliary duct obstruction (compared with pretreatment values) | No | Yes | ||
Abbreviations: CR, complete response; IRE, irreversible electroporation; MRI, magnetic resonance imaging; PD, progressive disease; PR, partial response; SD, stable disease.