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. 2019 Aug 15;47(9):e727–e734. doi: 10.1097/CCM.0000000000003841

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Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine and Wolters Kluwer Health, Inc.

This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Bacterial composition in age-matched critically ill and healthy children. Nonmetric multidimensional scaling (NMDS) plot of fecal microbial composition at genus level. High variability is seen in samples from critically ill children (red) compared with healthy controls (orange). PERmutational Multivariate ANalysis Of Variance (PERMANOVA) p = 0.0001, F = 3.314. Samples from healthy children were tightly clustered together, suggesting greater similarity in composition, while those from patients were scattered widely across the plot and statistically separated from the healthy profiles (PERMANOVA test: F = 9.78; p < 0.001).