Table 1. MS analyses of EV-HDL and EL-HDL lipids.

AU/mg HDL protein	EV-HDL	EL-HDL	p-value
PC	461.7 ± 19.39	172.1 ± 5.73	0.0001
PE	18.01 ± 0.35	3.53 ± 0.22	< 0.0001
PI	156.0 ± 6.25	4.01 ± 0.13	< 0.0001
TAG	51.67 ± 1.79	19.52 ± 1.91	0.0003
DAG	45.74 ± 1.52	11.88 ± 0.42	< 0.0001
LPC	41.37 ± 0.68	108.2 ± 3.80	< 0.0001
LPE	0.16 ± 0.004	0.19 ± 0.003	0.0033
FA	223.3 ± 6.78	1834 ± 222.1	0.0019
FC	0.95 ± 0.05	1.32 ± 0.05	0.0067
CE	1036 ± 16.06	1051 ± 102.0	0.8936
Cer	4.065 ± 0.10	5.229 ± 0.14	0.0025
SM	67.89 ± 2.24	75.17 ± 4.58	0.2265

Lipids from EV-HDL and EL-HDL (300 μg protein) purified by ultracentrifugation followed by FPLC were extracted and analyzed by MS. Results are mean ± SEM of 3 independent modifications of human HDL. The differences between EV-HDL and EL-HDL were analyzed by two-tailed unpaired t-test between EV- and EL-HDL. P-values of < 0.004 are considered significant after a Bonferroni correction for multiple testing. PC, phosphatidylcholine; PE, phosphatidylethanolamine; PI, phosphatidylinositol; TAG, triacylglycerol; DAG, diacylglycerol; LPC, lysophosphatidylcholine, LPE, lysophosphatidylethanolamine, FC, free cholesterol, CE, cholesteryl ester; Cer, Ceramide; SM, Sphingomyelin; MS, mass spectrometry; SEM, standard error of mean;