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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Nat Med. 2019 Jul 1;25(7):1096–1103. doi: 10.1038/s41591-019-0495-2

Extended data table 1. Baseline Participant Characteristics.

Parameters Placebo (n = 11) Pasteurized (n=12) Alive (n = 9) Ptotal P1 P2
Age (years) 49,45 ± 9,67 52,75 ± 7,16 52,89 ± 8,59 0,58a 0,36 0,42
Sex (nb (%))
   Male 5 (45) 4 (33) 6 (67)
   Female 6 (55) 8 (67) 3 (33)
Height (cm) 173,05 ± 9,32 170,54 ± 8,8 172,11 ± 10,15 0,81a 0,52 0,83
Body Weight (kg) 112,45 ± 16,74 115,91 ± 17,23 109,03 ± 13,96 0,63a 0,63 0,63
BMI 37,63 ± 5,82 39,81 ± 4,77 36,82 ± 3,68 0,35a 0,34 0,72
Waist (cm) 120,2 ± 12,51 126,46 ± 8,75 120,06 ± 10,43 0,29a 0,19 0,97
Hip (cm) 118,8 (12,4) 123,46 (7,8) 117,83 (16,5) 0,22b 0,13 0,65
Waist-hip ratio 1,02 ± 0,11 1,03 ± 0,09 1,02 ± 0,10 0,97a 0,82 0,94
Systolic blood pressure (mm Hg) 150 (12) 150,00 (20) 140,00 (19) 0,15b 0,38 0,18
Diastolic blood pressure (mm Hg) 90,00 (9) 102,50 (19) 100 (19) 0,08b 0,02 0,44
Fasting Blood glucose (mg/dl) 100,33 (11,67) 103,00 (15,08) 94,33 (18,5) 0,34b 0,24 0,82
Glycated hemoglobin A1c (%) 5,53 ± 0,36 5,77 ± 0,42 5,63 ± 0,35 0,33a 0,11 0,52
Insulinemia (pmol/L) 111,36 (28,83) 155,83 (57,01) 128,7 (86,42) 0,030b * 0,014 * 0,47
% insulin sensibility 34,00 (8,5) 23,75 (9,17) 30,8 (21,65) 0,025b * 0,007 * 0,5
Total Cholesterol (mg/dl) 200,73 ± 43,19 203,00 ± 51,34 198,67 ± 20,47 0,97a 0,91 0,9
LDL Cholesterol (mg/dl) 131,63 ± 37,64 129,92 ± 41,10 128,78 ± 18,63 0,98a 0,92 0,84
HDL Cholesterol (mg/dl) 42 (7) 44,5 (12,25) 43 (18,5) 0,70b 0,41 0,82
Ratio (tot cholesterol/HDL) 4,65 ± 1,05 4,59 ± 1,14 4,84 ± 0,92 0,86a 0,91 0,61
Aspartate aminotransferase activity (U/L) 17,00 (8) 23 (17,75) 20 (11,5) 0,26b 0,12 0,49
Alanine aminotransferase activity (U/L) 21 (14) 37,5 (26,25) 30,78 (28,5) 0,14b 0,42 0,34
ɣ-Glutamyltransferase activity (U/L) 21 (17) 40,5 (51) 27 (5) 0,084b 0,45 0,13
Lactate dehydrogenase activity (UI/L) 166 (21) 197,5 (41,75) 180 (50) 0,082b 0,023 0,46
Creatine kinase (U/L) 90 (64) 96 (100) 111 (48,50) 0,68b 0,48 0,33
Triglycerides (mg/dl) 127,45 ± 46,49 139,83 ± 47,79 135,56 ± 44,13 0,84a 0,58 0,69
DDPIV activity (mU/ml) 14,72 (4,45) 15,58 (7,67) 13,89 (3,13) 0,12b 0,36 0,18

ptotal: aP-values from one-way ANOVA except for Sex; bP-values from Kruskal-Wallis.

P1-2 = P-values for comparison of Placebo groups versus Pasteurized group (P1) and versus Alive group (P2) with the two-tailed Mann-Whitney U test or two-tailed unpaired T-test according to the distribution, with p > 0,017 due to the Bonferroni adjustment. Baseline values are presented as mean + SD for normal variables while non-normal variables are presented as Median (inter-quartile range).

*

Significant difference between groups value (P < 0.05 for Ptotal ; P < 0.017 for P1 & P2)